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Individuals with Gut Absorption Issues : Conditions like Crohn's disease, celiac disease, or pernicious anemia (an autoimmune condition where the body can't produce intrinsic factor, a protein needed for B12 absorption) can significantly impair B12 uptake

The rush of vitamins and hydration will leave you skipping out

Often split into two injections: 250mcg fasted AM and 250mcg pre-bed

When patients with hepatitis C were given standard therapy or standard therapy with a B12 injection of 5,000mcg, every 4 weeks for 48 weeks, those with the additional B12 responded better to treatment (18)

High-dose oral vitamin B12 supplements (1000-2000 micrograms per day) have also been shown to raise levels, because high doses can usually compensate for the bodys poor absorption