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Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility A 2-year carcinogenicity study was conducted with tirzepatide in male and female rats at doses of 0.15, 0.50, and 1.5 mg/kg (0.1-, 0.4-, and 1-fold the MRHD of 15 mg once weekly based on AUC) administered by subcutaneous injection twice weekly
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Digestive Issues : For some people, swallowing pills or capsules can be difficult, particularly for those with conditions such as dysphagia (difficulty swallowing)
Consequences of Excess Vitamin B12 Vitamin B12 is water-soluble, and excess amounts in the body can be easily excreted through urine, making it less toxic
