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Research indicates that an imbalance between free radicals and antioxidants can lead to endothelial dysfunction, a condition where the inner lining of blood vessels doesn't function correctly

doi: 10.1038/s42003-020-0986-1 20 DingRLiHLiuYOuWZhangXChaiHet al

While animal models have partially deciphered these mechanisms, human studies face substantial challenges: interindividual microbiota variability and confounding environmental exposures (e.g., antibiotic history) complicate causal inference