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Its late diagnosis, which is only possible in an advanced illness stage, is one of the key problems

It may be that the benefit of the CRWP may not be limited to its efficacy at increasing antioxidant capacity, but its ability to improve overall health

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However, there is compelling evidence that caspase-3 and caspase-8 are downstream effectors of the Fas cell death signaling pathway, indicating their importance for extrinsic Fas-mediated eryptosis (see the Extrinsic Fas-mediated eryptosis section) [130, 136]