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Clinically, solar lentigines measure larger (5-20mm) compared to freckles (1-3mm) and exhibit more irregular pigment distribution under dermoscopy

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These include HSPB1 (HSP27), HSPB5 (B-crystallin), HSPB6 (HSP20), HSPB7 (cardiovascular HSP), and HSPB8 (HSP22)

Semaglutide and liraglutide are injectable GLP-1 receptor agonists that target these incretin receptors to take advantage of the latter effects to promote weight loss