The pills haven't been compared head-to-head in a clinical trial, but in separate studies, the Wegovy pill showed average weight loss of 14% over 64 weeks, compared with 2% for a placebo, while orforglipron showed 11% weight loss over 72 weeks on its highest dose, compared with 2% for the placebo group
New symptoms appearing after starting supplements could indicate interactions, inappropriate dosing, or sensitivity to specific ingredients
Health + Medication Plan: Includes access to a weight loss prescription, regular video visits with a physician and registered dietitian, ongoing care and monitoring, and options for labs, genetic testing, and sleep apnea assessments
There have been some studies linking the supplements with more muscle and less fat in people with normal levels of GH, but nothing definitive
PLoS One 6:e27260