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The subjective nature of muscle discomfort and gastrointestinal issues reported by patients, such as heartburn and gas, illuminates the variability with which individuals experience the withdrawal from semaglutide

Clinicians are raising concerns, too

This combined approach has been shown in studies to support long-term weight management in eligible individuals

This occurs because the appetite-suppressing effects of semaglutide cease, often leading to increased hunger and caloric intake

Curious to learn more about the effect of GLP-1 on appetite, in 1998 Holst and collaborators at the University of Copenhagen undertook a placebo-controlled, randomised study with 20 healthy young men between the ages of 20 and 31