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First, too much glutamate is toxic to the very architecture of the brain

Journal of Dermatological Treatment 23: 97-102 (2012) Birben E, Sahiner UM, Sackesen C, Erzurum S, Kalayci O

An accumulation of excess intracellular oxidants can promote redox-mediated signaling events, including antioxidant responses, such as the activation of nuclear factor erythroid 2-related factor 2 (Nrf2) [3], as well as promote the activation of proinflammatory pathways that are mediated by redox-sensitive transcription factors, such as nuclear factor kappa B (NFB) and activator protein 1 (AP-1) [46]

Future studies will optimize antibody screening to supplement protein-level detection and further elucidate the underlying molecular regulatory mechanisms