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Subsequent immunofluorescence staining revealed colocalization of FG signals with approximately 95% of DMV cells positive for choline acetyltransferase (ChAT), a marker of cholinergic neurons (Supplementary Fig

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Peptide clearance depends on: Half-life (short vs long-acting compounds) Route of administration (subcutaneous vs intramuscular) Structural modifications (e.g., PEGylation or DAC binding) Metabolic rate and enzymatic activity Short-acting peptides like GHRP-6, Ipamorelin, and Tesamorelin are typically cleared within 2448 hours

Moreover, targeted inhibition of mitochondrial iron overload by overexpressing FTMT markedly inhibited oxidative stress-induced mitochondrial lipid peroxidation and ferroptosis