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Research suggests that the SARS-CoV-2 virus can directly hijack mitochondrial function during the acute infection phase, altering the mitochondrial membrane potential and downregulating the expression of key metabolic enzymes

ER zinc dysregulation The ER is highly sensitive to perturbations in zinc homeostasis, and disturbances in luminal or cytosolic zinc can initiate maladaptive stress responses that contribute directly to human disease

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JAMA 296 (1), 5663 (2006) L