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Specifically, Gclc ablation in FoB induces metabolic features of wild-type MZB such as increased ATP levels, glucose metabolism, mTOR activation, and protein synthesis

Additionally, it negatively regulates the Nrf2 inflammatory pathway, contributing to its anti-inflammatory effects (Yanguas-Cass et al., 2017

Based on domain architecture comparison with HNF4 58,59 , we engineered an NHR-49 truncation (295422) to disrupt ligand binding by removing a majority of the ligand binding domain, while retaining its analogous N-terminal, DNA-binding, hinge, and C-terminal domains (Fig

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While Decitabine may not directly inhibit tumor growth, its ability to block DNA methylation enhances tumor sensitivity to various chemotherapy agents, including carboplatin, cisplatin, and 5-FU [22]