Before GLP-1s like Ozempic were approved, earlier trials tested a range of doses and found that lower doses produced some weight loss and blood sugar improvements
For compounded semaglutide specifically, treatment duration considerations are similar, but access and cost dynamics differ
Beyond the general DKD risk conferred by obesity, fat accumulation in depots anatomically close to the kidney as well as intrakidney fat accumulation has been linked to kidney disease
This article examines the current evidence on investigational GLP-1 patches, including potential wearing durations, application methods, and safety considerations, whilst highlighting the licensed injectable alternatives available through the NHS
However, this research is in the very early stages, and no GLP-1 medication can currently be successfully delivered through the skin