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Bommareddy is with the Department of Dermatology, Larkin Health System, South Miami, Florida

The contribution of inflammatory intermediates such as eicosanoids in cancer initiation and progression is another area of interest

In OA models induced by interleukin-1 beta (IL-1) and ferric ammonium citrate (FAC), hallmark ferroptosis markers such as glutathione peroxidase 4 (GPX4) and solute carrier family seven member 11 (SLC7A11) exhibit significant downregulation, whereas expression levels of the tumor suppressor gene p53 and acyl-CoA synthetase long-chain family member 4 (ACSL4) are elevated (Yao et al., 2021)

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Relative contraindicationssuch as severe renal impairment, active pancreatitis, or uncontrolled psychiatric conditionsrequire provider discussion and possible alternative therapy