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Pregnant individuals, those with severe renal or hepatic impairment, and patients with a history of pancreatitis require specific clinical evaluation

review (European Journal of Pharmacology, 2024) notes that the albumin-binding design "supports once-weekly subcutaneous administration" and that the long half-life is a key feature of the pharmacokinetic profile

The same analysis flagged a higher adverse-event relative risk for retatrutide (RR 4.10 vs 2.78), consistent with a higher gastrointestinal burden at the top doses

Trimi's citations of STEP 1, SURMOUNT-1, and SELECT are accurate and appropriately attributed

Le Roux 1