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An RCT in patients receiving cisplatin chemotherapy found that NAC (1,200 mg/day) significantly reduced nephrotoxicity and ototoxicity without reducing antitumor efficacy (Riga et al., Am J Clin Oncol, 2013) [77]

Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency

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doi: 10.1038/srep10048 132

Therefore, cerebral serotonin is synthetized in the brain, where it plays a major role in mood regulation and, after transformation in melatonin, in sleep regulation (155, 156), as summarized in Figure 1