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The high-mobility group box-1 (HMGB1) protein is a pro-inflammatory nuclear protein that is passively released and targets Toll-like receptors (TLR) to alert the immune system of dying cells (Lotze and Tracey 2005

Evidence from murine models of hepatic fibrosis suggests that ILC2s may contribute to fibrogenesis through IL-13-dependent mechanisms (113) ( Figure 5C )

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