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Tirzepatide is not recommended during pregnancy, and women of reproductive potential should discuss contraception with their healthcare provider

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Additionally, while semaglutide generally has a favorable liver safety profile and has been approved (as Wegovy) for treating metabolic dysfunction-associated steatohepatitis (MASH) with moderate-to-advanced fibrosis based on phase 3 trials showing histological improvements, rare post-marketing cases of hepatotoxicity (elevated liver enzymes, jaundice) have been reported, typically resolving upon discontinuation