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This is a common strategy in medicine, using a safer agent to reduce dependence on a riskier one, but it requires careful monitoring to ensure disease control is maintained

They added GHK-Cu in concentrations of 10 M to 10 M and measured: Collagen synthesis (by radioactive proline incorporation) Non-collagen protein synthesis Cell proliferation What they found: Stimulation of collagen synthesis by 70 % at the optimal concentration of 10 M (1 nM) The effect was NOT dependent on increased proliferation, fibroblasts increased production per cell Background: GHK without copper had a dramatically weaker effect , Cu is critical Reversibility: After removing GHK-Cu, synthesis returned to baseline Why it matters: This is the fundamental mechanistic study that documented the effect of GHK-Cu on collagen

Journal of Molecular Neuroscience, 72(6), 13001312

As we age, the bodys capacity to produce glutathione decreases

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