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For a person weighing 175 lb (approximately 80 kg), this means daily doses between 250 and 500 micrograms, typically expressed as 0.25 to 0.5 mg

Autotomy that occurs long after injury may appear as pain that occurs below the level of the injury (below-level pain) [64, 65], and the late spontaneous worsening may be the result of complete deafferentation of one or several spinal segments the stimulation of the nerve plexus, or dorsal root injury [66]

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These include vegetarians, vegans, older adults, and those with stomach problems