These results were further supported by another study from the same lab, whereby GLP-1 was shown to stimulate myocardial glucose uptake via mechanisms that were p38 MAP kinase and NO dependent, but independent of adenylyl cyclase or Akt [73]
Despite not being a primary aim of the study, by collecting participant characteristics we saw clinically significant improvements in physical health (weight and HbA1c), of similar magnitude to that seen in trials of GLP-1 receptor agonists in obesity [35] and T2D and overweight [36, 37]
Semaglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist that mimics a hormone to increase insulin secretion, slow gastric emptying, and reduce appetite
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