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The high glucose environment in diabetic patients can promote the intracellular activation of polyols and protein kinase C (PKC) pathway to form AGES, as well as glomerular hypertension induced by glomerular hyperfiltration, and then promote the occurrence of DN inflammation through downstream inflammatory factors (24)

Robinson E, Cassidy RS, Tate M, Zhao Y, Lockhart S, Calderwood D, Church R, McGahon MK, Brazil DP, McDermott BJ