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The current knowledge of the effects of changes in brain redox state on organismal longevity suggests that cyclic reductive shifts in the neural mitochondrial [NAD + ]/[NADH] are associated with lifespan extension

It is not yet clear though if smaller variations in dietary niacin intake can negatively affect brain function

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Benzodiazepines and Other CNS Depressants Due to additive pharmacologic effect, the concomitant use of benzodiazepines and other CNS depressants, such as benzodiazepines and other sedative hypnotics, anxiolytics, and tranquilizers, muscle relaxants, general anesthetics, antipsychotics, gabapentinoids (gabapentin or pregabalin), and other opioids, including alcohol, can increase the risk of hypotension, respiratory depression, profound sedation, coma, and death

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