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One major reason is the availability of skilled manpower and modern facilities

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Methods: Nineteen WD and four heterozygote control rats were injected intravenously with [ 64 Cu] and scanned one hour later

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The molecule is small enough to cross the epidermal barrier to some degree, but reaching fibroblasts in the mid-to-deep dermis where the structural work happens requires either injection or a delivery mechanism that bypasses the barrier