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the original rodent study used 5 mg/kg, which when scaled allometrically to human equivalents suggests doses in the 5-10 mg range for a 70 kg adult, though allometric scaling from mice to humans is an imprecise science

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Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in type 2 diabetes (J-DOIT3): an open-label, randomised controlled trial

Thats where GLP-1 medications can benefit patients with Hashimotos

Vitamin B12 shots may not be suitable for people with a history of: sensitivity to vitamin B12 Lebers disease, which affects the optic nerve kidney problems hypokalemia (low potassium levels) deficiencies in other nutrients, particularly folic acid and iron Vitamin B12 injections typically begin to work straight away