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In a study involving a large group of individuals with type 2 diabetes, insulin resistance (IR) was found to be a significant factor in predicting both the prevalence of CVD at the beginning of the study and the occurrence of new cases of CVD during the follow-up period

However, it is crucial to note that KEAP1 is only one member of a larger group of 42 Kelch-BTB proteins, each exerting essential roles in biological processes, primarily through substrate ubiquitination (Shi et al., 2019)

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