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10.3390/molecules28083630 34 DongW.ZhangH.ZhaoC.LuoY.ChenY

The reduction of glutathione peroxidase 4 (GPX4), an enzyme that lowers lipid hydroperoxides and inhibits lipid peroxidation, is one important mechanism (67)

Combats muscle wasting: Glucocorticoids can cause muscle loss, but GH and secretagogues have shown promising effects

A predicted site in selenoprotein P (SELENOP, Figure 2C) is at position 56, 3 residues prior to the first selenocysteine, such that cleavage here would likely interfere with the N-terminal redox activity, possibly without affecting the Se-transport function of the rest of the protein

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