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Dual glucagon-like peptide-1 receptor/glucagon receptor agonist SAR425899 improves beta-cell function in type 2 diabetes
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Mechanistically, this complementarity is plausible: while surgery provides mechanical gastric restriction and alters gut hormone profiles, its inability to fully correct the underlying energy homeostasis dysregulation in MC4R deficiency often leads to long-term weight regain [43,45]
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