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& Costantini, I
Best GLP-1 Medications in the UK There are three main GLP-1 medications used for weight management in the UK: Mounjaro, Wegovy, and Saxenda
Wegovy is FDA-approved for weight management in adults with a BMI of 30, or 27 with weight related comorbidities
Meta-analyses confirm that physician-supervised pharmacotherapy outperforms lifestyle changes alone
This guide breaks down the pharmacology, the mechanistic contrast, the head-to-head trial evidence (including the 2025 SURMOUNT-5 results), what enthusiast and research communities online are saying, and the practical realities of sourcing both compounds in Canada
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