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LKB1, a tumor suppressor, is a major mammalian AMPK kinase in the liver that activates AMPK by phosphorylating the Thr172 residues of AMPK subunits
Per ASCO guidelines, duloxetine is the only agent with moderate evidence for CIPN pain relief
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Tobacco Etch Virus (TEV) Protease TEV protease is a cysteine protease from Tobacco Etch Virus that recognizes the ENLYFQS/G consensus and cleaves with high sequence specificity, enabling precise tag removal with minimal residual amino acids (often only the natural N-termial residue) [160]
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