10.1038/s41401-020-00531-1 Acta Pharmacol
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GLP-1 RAs exerted neuroprotective effects by inhibiting glutamate accumulation to prevent excitotoxicity and neural apoptosis [39], which possibly explains the protective effects of the GLP1R gene on background DR and severe nonproliferative DR, but not proliferative DR
Adequate hydration and dietary fiber intake help manage this side effect
Drug working concentrations and stock preparation were as follows: GLP-1MK-801 and MK-801 (both 50 M, dissolved in aCSF or magnesium-free aCSF), NMDA (100 M, dissolved in magnesium free aCSF), CNQX (10 M, dissolved in DMSO, Alomone Labs), picrotoxin (100 M, dissolved in DMSO)