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By initiating the breakdown of L-tyrosine in the proximal region of the small intestine with consequent reduction of the quantity reaching the colon and by competing with the native gut microbiota in the colon implicated in p-cresol generation from L-tyrosine, the therapeutic strain exerts its activity in CKD patients

It is an endogenous neuropeptide found naturally in airway nerve terminals and mast cells, with potent anti-inflammatory and bronchodilatory properties

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In eight CVOTs history of heart failure was reported at baseline and it ranged from 9% to 24% with no significant difference between patients receivng GLP-1 receptor agonist and patients receiving placebo

Funding This work was supported by the State Committee of Science RA (N 10-14/23-I/YSMU and 20TTCG-3A012) and the EU-funded H2020 COBRAIN project (857600)