1 Introduction Schizophrenia (SZ) is a chronic brain disorder characterized by genetic heterogeneity and neuropathological alterations, with high mortality rates ( Current evidence from genetics, molecular neuropathology, and clinical studies underscores the importance of immune factors in both the pathogenesis and treatment of schizophrenia ( Figure 1 )
The same corresponds to the effect of age and aging on the brain barrier functions and the related effects of Se and selenoproteins ( Many studies indicate the critical importance of the exact chemical speciation of essential trace elements (Templeton et al., 2000) in determining their biological activity (Michalke et al., 2018)
Kawaida, K., Matsumoto, K., Shimazu, H
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