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In a large clinical trial, people with obesity but not diabetes taking semaglutide for more than 3 years had a 20% lower risk of heart attack, stroke or death due to cardiovascular disease and lost an average of 9.4% of their body weight

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Real-world observational studies examining clinical data have not identified consistent patterns of increased rates of general vision problems associated with GLP-1 use, though most studies were not specifically designed to detect rare ocular events

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