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Clinical confirmation and verification of result reproducibility remain a mandatory next step
In mouse models of NASH, GLP-/GIP dual agonists have also been found to significantly reduce TG and LDL-C and increase high-density lipoprotein cholesterol (HDL-C) [127]
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For context, losing 5kg of body weight typically reduces systolic blood pressure by about 4 to 5 mmHg on its own
Ferroptosis drives the further occurrence and development of DR through lethal ROS accumulation, iron overload, and uncontrolled lipid peroxidation, leading to RPE cell damage and death
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