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Enzyme-based linkers are utilized most commonly in ADCs: 8 out of 13 FDA-approved ADCs use a protease-cleavable linker, including the ADCs enfortumab vedotin and trastuzumab deruxtecan that have transformed the standard of care for metastatic urothelial and breast carcinomas 54

Ferroptosis in Cancer Progression: Role of Noncoding RNAs

P-glycoprotein is expressed in intestinal mucosa, renal proximal tubules & in capillary endothelial cells comprising the blood-brain-barrier, and in tumor cells (where it functions as a multi-drug resistance mechanism)

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