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If you take insulin or similar diabetes medications, you may be more likely to experience hypoglycemia, including severe hypoglycemia, on Zepbound

This depends on your starting weight and how your body responds

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Table 3: Changes in Anthropometry and Cardiometabolic Parameters at Week 72 in Studies 1 and 2 in Patients with Obesity or Overweight Weight Reduction Following Intensive Lifestyle Intervention In Adults With Obesity Or Overweight (Study 3) Overview Of Study 3 Study 3 (NCT04657016) was an 84-week trial with a 12-week intensive lifestyle intervention lead-in period (Week -12 to Week 0), followed by a 72-week randomized treatment period of ZEPBOUND versus placebo (Week 0 to Week 72) with a standard lifestyle intervention