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Preclinical safety evaluations revealed no toxicity in acute studies with SD rats and beagles following intravenous/intramuscular administration [10]
The peptide has been administered at doses far exceeding those used therapeutically without significant adverse effects
At the 4 mg amount, 92% of participants achieved at least 5% weight reduction, 75% achieved at least 10%, and 60% achieved at least 15%
Thereby, more use of models of inflammatory bowel disease (and in particular, more effectiveness in cysteamine colitis rats with colon-colon anastomosis), better evidence for multiple sclerosis models (especially, cuprizone application) would be ascertained