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Even higher thresholds apply in the Highly Specialized Technologies (HST) program, intended for ultra-orphan diseases: here allowances can reach on the order of 100k300k per QALY ( [5] ), recognizing the exceptional rarity and need for innovation

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Many patients have also reported improvements in insulin resistance, reduced inflammation, and fewer struggles with food-related preoccupations

Despite these positive findings, the study is not without its limitations