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This is a significant phenotype, as a similar reduction in circulating triglycerides was not observed with a liver-specific loss of critical lipogenic enzymes, such as fatty acid synthase (FASN) 81

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Specifically, the 12 mg arm of retatrutide has shown the highest discontinuation figures of the three compounds at their respective top doses, though investigators have suggested that part of the rate reflects participants who reached weight loss thresholds and chose to discontinue