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Further accumulation of uremic toxins, which leads to uremic syndrome, can, among others, cause neurotoxicity, disruption in the BBB integrity, oxidative stress, neuroinflammation, and disturbance of brain neurotransmitter amino acids balance (Hamed, 2019)

10.1002/1873-3468.13090 29 GliubichF.BerniR.ColapietroM.BarbaL.ZanottiG

We measured phase I and II cytochrome P450 enzymes, glutathione, reactive oxygen species, cytokines including Il6 , and pSTAT3 by reverse transcriptase quantitative PCR, colorimetric, immunohistochemistry analyses and Western blotting

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The study also highlighted AOD9604s influence on fat metabolism and energy expenditure, and its interaction with 3-adrenergic pathways [2]