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The observed decrease of peroxisomal Cit2 activity in aspirin-treated EG110 yeast cells (Table 2) indicates that the glyoxylate cycle, which facilitates transport of acetyl-CoA-derived succinate (a TCA cycle intermediate) to the mitochondria 38 is possibly impaired by aspirin much like the carnitine shuttle pathway

Biophys J , 96 (3), 11421150

Individuals with B12 deficiency often report symptoms similar to those of anxiety and depression, such as irritability and cognitive difficulties

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Most often, symptoms get worse over many years