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This antioxidant function connects MOTS-c to the suppression of oxidative stress, one of the canonical drivers of biological aging

PMID 31193945

I was also cold all of the time, despite being on thyroid meds

It's not about global signaling in the same way some peptides are

Research investigations commonly explore the compound in experimental models examining: Peptide signalling pathways Regulatory network interactions Peptide interaction dynamics Intracellular signalling mechanisms Comparative peptide research Molecular signalling pathway analysis Receptor interaction modelling These experimental models allow scientists to investigate molecular mechanisms involved in peptide-mediated signalling processes