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Side Effects & Safety Per REDEFINE 1 and the Lau (2021) phase 2 program, trial-reported adverse events include: Nausea -- most common (25-40%)

Tan IIA induced activation of the GSH system to attenuate cardiac oxidative stress and restrain the increase in serum myocardial enzymes, thus relieving the extent of myocardial damage [154, 155]

Reduced efficacy manifests as return of appetite, slower weight loss, or a feeling that the medication has stopped working

A gradual reduction minimizes this spike and gives your eating behavior time to re-stabilize

Patients with type 2 diabetes, treated with metformin alone or treated with metformin and a second OAD treatment that could be a sulfonylurea or a glinide or a sodium-glucose cotransporter-2 (SGLT-2) inhibitor or a dipeptidyl peptidase-4 (DPP-4) inhibitor, and who were not adequately controlled with this treatment (HbA1c range 7.5% to 10% for patients previously treated with metformin alone and 7% to 9% for patients previously treated with metformin and a second OAD treatment) entered a run-in period for 4 weeks