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However, something concerning the researchers came across in their review was people with anxiety and depression sometimes experience worsened symptoms

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The protective effects of NAC were mediated through two primary mechanisms: the inhibition of CDK5-dynamin-related protein 1 (DRP1) signaling and the modulation of the glutathione peroxidase 1 (GPx1)-nuclear factor kappa B (NF-B) pathway

As intracellular GSH is exhausted, the GSH synthesis system will be activated accordingly, which would weaken the efficacy of GSH exhaustion-based cancer therapies in long-term treatment (Niu et al., 2021)