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Contraindications include active malignancy (GH/IGF-1 could theoretically promote tumor growth, though evidence is mixed), hypersensitivity to Sermorelin or GHRH, pituitary tumors or masses (stimulation could theoretically promote growth), and pregnancy/lactation (safety not established)

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However, since the GLP-2 treatment ex vivo was for 45 min (Hsieh et al., 2009), and that GLP-2 treatment rapidly induces the mobilization of pre-formed chylomicrons by 1 h treatment in humans (Dash et al., 2014), this increase in apoB48 synthesis may be driven by clearing the preformed particles earlier than vehicle controls

[42] Many pregnant women experience hyperpigmentation on their thighs, stomach, face, and hands