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With a few drugs, such as phenylbutazone, ethanol, deracoxib, and phenytoin, or if very large doses of a drug are given, the drug concentrations achieved are much greater than K m and the rate equation is as follows: The enzymes are saturated by the high free drug concentrations, and the rate of metabolism remains constant over time

Lih-Brody L, Powell SR, Collier KP, Reddy GM, Kahn E, Weissman GS, Katz S, Floyd RA, McKinley MJ, Fisher SE, and Mullin GE (1996)

doi: 10.1016/j.bbrc.2011.06.004 170 HwangJ

It plays an important role in the synthesis of haemoglobin, creatine, porphyrin, bile salts, glutathione, DNA and RNA

Molecular genetic analysis of the APEX nuclease gene in amyotrophic lateral sclerosis