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Regrettably, patients with nail apparatus melanoma are often initially misdiagnosed, and due to diagnostic delays of an average of 2 years, melanoma of the nail unit carries a poor prognosis

Before advancing these strategies to clinical application, several key challenges must be addressed, such as the complexity and functional redundancy of the ferroptosis regulatory network, the limitations of existing animal models in simulating the pathological features of human chronic OA, and the lack of reliable biomarkers for assessing intra-articular ferroptosis activity in humans

1 Design of the clinical trial phase 1 and 2

10.1016/j.biochi.2010.06.009 62 KimK.PortisJ

Squillacioti C, Pelagalli A, Liguori G, Mirabella N