The one exception is patients with Wilson's disease, a genetic condition that impairs copper excretion and leads to dangerous copper accumulation
Some studies show effects on certain measures but not others
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Intra-articular/soft-tissue injection: The dose depends on the size of the joint or lesion. A general guideline (from FDA labeling) is: Large joints (knee, ankle, shoulder) 2080 mg (0.52 mL); Medium joints (elbow, wrist) 1040 mg (0.251 mL); Small joints (fingers, toes) 410 mg (0.10.25 mL). Tendon sheath or bursa injections usually use 430 mg. For example, a knee might receive 40 mg once, while an inflamed finger joint might get 5 mg. Practitioners often aspirate synovial fluid first to confirm needle placement, then inject Depo-Medrol into the joint space. The joint is gently moved afterward to mix the steroid suspension. Repeat injections (if needed) are typically spaced by several weeks (e.g. 46 weeks) to monitor response and avoid excess steroid exposure
state that despite a paucity of supporting evidence, many experts will tolerate a few daily seizures to mitigate the risk of complications associated with profound sedation. (38117319) [#4] lift sedation to determine if seizures can be controlled off anesthetic infusions Anesthetic infusions are weaned off (while continuing maintenance antiseizure medications)
