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Endotext (2024) Once-weekly semaglutide in adults with overweight or obesity, New England Journal of Medicine (2021) Weight regain and cardiometabolic effects after withdrawal of semaglutide: The STEP 1 trial extension, Diabetes, Obesity and Metabolism (2022) Medically accurate: SingleCares Medical Review Board analyzes all of our content to confirm its in line with current medical advice

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Interestingly, the neural circuits responsible for the metabolic effects of GLP-1R agonism may be distinct from those mediating nausea or malaise (Huang et al., 2024), suggesting that future therapies could be tailored to preserve metabolic benefits while minimizing gastrointestinal side effects

10.1096/fj.02-0401fje 104 TianW.RocksonS

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