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For others, weight loss from GLP-1 drugs results in reduced heaviness, soreness or fatigue in their legs

Ambas hormonas, GLP-1 y GIP, son parte de un grupo llamado incretinas, que ayudan a regular cmo funciona nuestro metabolismo

The enzyme prohormone convertase (encoded by the PCSK1 gene) then cleaves proglucagon into several active peptides, including GLP-1

Natural GLP-1 cannot be used therapeutically because it is rapidly degraded by the enzyme DPP-4 within 1-2 minutes, requiring continuous intravenous infusion for sustained effect

Note that the figure shows descriptive summary statistics of the data (raw data), whereas we report the estimated means and the mean difference from statistical models in the results (linear mixed-effect model with trial arm as a single fixed effect and patient as a random effect)